Wound Healing Society

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3d Patient Specific Implant For Craniofacial Reconstruction
JongWon Rhie1, Hyunho Han2, Jin Hyung Shim3, Dong Woo Cho4, Chung Hwan Baek5.
1The Catholic University of Korea, Seoul St. Marys Hospital, Seoul, Korea, Republic of, 2Seoul Asan Medical Center, Seoul, Korea, Republic of, 3Korea Polytechnic University, Seoul, Korea, Republic of, 4Pohang University of Science and Technology, Pohang, Kyungbuk, Korea, Republic of, 5Seoul Samsung Medical Center, Seoul, Korea, Republic of.

Background: Management of significant facial bone defects or asymmetry are challenging. Conventional options include autogenous bone grafts or alloplastic implants. However, bone grafts are limited by donor morbidity, unpredictable results and long operation time. Alloplastic implants are mainly non-absorbable and may cause foreign body reaction. We present the application of a 3D-printed patient specific absorbable mesh implant for reconstruction of bone defect caused by tumor resection.

Methods: A customized polycaprolactone (PCL) scaffold was designed and fabricated for each patient. For this purpose, we used computer-aided design and manufacturing combined with 3D printing technology. The patients implanted with the PCL scaffolds were followed up for up to 2 years with careful evaluation of morphological changes in the face. We have experienced 5 more clinical case of craniofacial reconstruction with patient specific 3 D printed implant.

Results: We confirmed that the patient-specific 3D-printed PCL scaffold effectively filled the maxillary defect and promoted regeneration of the deficient tissue while remaining stable in the body for a relatively long period of time.

Conclusions: Employing customized tissue-engineered scaffolds built using the patient's CT data and an extrusion-based 3D printing system is safe and clinically feasible, helping create and maintain improved morphological features of the face, which represents the most important aspect from the perspective of the patients.


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