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The Use Of Acellular Dermal Matrix Paste For Treatment Of Diabetic Foot Ulcer
Konkuk University Medical Center, Seoul, Korea, Republic of.

BACKGROUD: Management of diabetic foot ulcer can often present challenging and complex problems. The purpose of this clinical trial study was to evaluate efficacy and safety of a paste-type acellular dermal matrix (ADM) product (CG paste, CGBio, Korea) in the treatment of diabetic foot ulcer. METHOD: This was a randomized, controlled, single-center study in which patients with diabetic foot ulcers. 49 patients with diabetic foot ulcers were randomized to either the ADM paste treatment group (n = 23) or the control group treated with simple dressing (n = 26). Before, all ulcers were subjected to debridement and irrigation to control infection. Then, the products were applied to the wounds and compressed gently to fill the wound cavities. Foam dressings were done to absorb the discharge. After 3 to 5 days, the dressings were removed and the wounds were inspected. Then the products were applied more times in serial. All procedures were done in the operating room. RESULTS: Ulcer healing was achieved in 70.17+-28.35(5), 83.25+-19.92(%), mean wound area and depth, of the treatment group and 45.82+-30.46(%), 40.96+-28.97(%) of the control group (p<0.05). The median times to complete closure were 17+-9.64 and 21.25+-5.85 days for the ADM paste and control groups, respectively. There were no complications after applying the ADM paste. CONCLUSION: Well grown granulation tissue is very important step for wound healing. The shortening the covering time with healthy granulation tissue leads to rapid wound healing. Our experience shows that the paste-type ADM product is very useful for enhancing the proliferation of granulation tissue.

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