Wound Healing Society

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Retrospective Analysis Of Over 300 Wounds From Porcine Wound Healing Studies Performed Over 6 Years
Anthony McElwain, Renee Munoz, Paul Attar, Sarah Korn, Kan Lam.
BRIDGE PTS, San Antonio, TX, USA.

BACKGROUND -Pigs are one of the most heavily utilized models for the development and testing of novel drugs and dressings in the field of wound healing. As a contract laboratory specializing in wound care, we have a large body of historical data on wound healing rates in Yorkshire pigs within a specific range of age and size. The purpose of this analysis was to compare the data from over 300 control wounds from multiple wound healing studies performed over a roughly 6-year period. METHODS -Data from these studies was collated and overall trends were delineated.RESULTS-The analysis shows that, in this model, a very reproducible time-frame for healing can be observed: with the granulation phase occurring from Days 0-4, the reepithelialization phase occurring from Days 4-14, and the remodeling phase occurring from Days 14-21. Extrapolated rates of change for these different periods are also reported. CONCLUSIONS- This data could be useful in future studies for the verification of normative wound behavior and as a baseline for comparison with novel wound healing agents or dressings designed to accelerate or decelerate wound healing.

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