Wound Healing Society

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New Materials For Rhinoplasty : Modified Polydioxanone Plate.
Chang-Hwan Ahn1, Sun Je Kim1, Su-Yeon Bae1, Jae-Yong Jeong2, Sang-Ha Oh1, Seung Han Song1.
1Cnungnam National University Hospital, Daejeon, Korea, Republic of, 2The PLUS Plastic Surgery, Seoul, Korea, Republic of.

Background Polydioxanone has been widely used in the medical field since about 30 years ago. In the 2000s, PDS foil began to be applied to rhinoplasty and septoplasty. However, in Asia PDS plates are not widely used due to lack of awareness and high prices. The author changed the process of the product from rolling extrusion method to flat die forging and lowered the price of the product. Also, we compare the biocompatibility of PDS plates (Ethicon Inc, Johnson & Johnson) and Newly developed materials in vivo and in vitro.
Methods In the in vivo experiments, the melting point and decomposition rate of DSC and TGA were evaluated and initial tensile strength was measured. In the in vivo experiments, implants of 1cm x1cm x0.15mm in size were inserted into the mice subcutaneously, and they were were harvested en bloc after 2, 5, 10, 15, and 25 weeks with hematoxylin-eosin and Masson’s trichrome to evaluate inflammation, extracellular matrix deposition, vascularization, and degradability.
Results There was no significant difference between PDS plates and Newly developed material in thermal analysis , tensilie strength test. Both products were completely degraded and were not observed in tissue slides in 25weeks. Histologic analysis showed similar results in inflammation, extracellular matrix deposition and vascularization.
ConclusionIn vivo and vitro experiments showed no significant difference in biocompatibility and degradability between newly developed material and PDS PLATE. The results of this study suggest that the use of absorbable graft materials may be more versatile in rhinoplasty and septoplasty.LEGENDFig. 1.
Fig. 2. Fig. 3. Fig. 4.


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