Wound Healing Society

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Patterns Of Pre-grafting Visual Characteristics And Outcomes Of Partial Thickness Burns Treated With Autograft Or A Skin Substitute
Angela Gibson, Lee Faucher.
University of Wisconsin, Madison, WI, USA.

Burn depth is a significant determinant of the time required for healing, and a major factor influencing long-term appearance and functional outcome. Making accurate predictions for time to healing and regenerative potential in indeterminate depth burns (IDB), a subset of deep partial thickness burns, is a challenge to burn surgeons. The management of IDB is becoming more sophisticated with the development of new excision tools and an increasing number of available tissue-engineered products. Despite the availability of newer and non-invasive imaging technologies for burn depth determination, visual assessment by a surgeon remains the standard of care. Often, in IDB cases, autologous grafting instead of a skin substitute is chosen as the method for wound closure, due to a concern for wound-healing outcomes. A better understanding of the wound-healing potential for IDBs may help surgeons develop methods to identify wounds that would benefit from a skin substitute rather than an autograft. Clinical data from pre- and post-operative images along with patient outcomes from a randomized clinical study provide context to aid in our understanding of wound healing as a function of wound depth. Here, we present an analysis from a randomized clinical trial to assess the relationship between wound depth and outcome, following treatment with a viable engineered skin tissue.


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