Wound Healing Society

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Use Of An Autologous Platelet And Leucocyte Patch Is Associated With Improved Usual Daily Activities In People With Diabetic Foot Ulcers
Magnus Londahl1, William Jeffcoate2, Lise Tarnow3, Judith Jacobsen, L4, Frances Game5.
1Skane University Hospital, Lund, Sweden, 2Nottingham University Hospitals Trust, Nottingham, United Kingdom, 3Steno Center Copenhagen, Copenhagen, Denmark, 4Universith of Copenhagen, Copenhagen, Denmark, 5Derby Teaching Hospitals NHS Foundation Trus, Derby, United Kingdom.

BACKGROUND: To evaluate the effect of using an autologous platelet and leucocyte patch on self-esteemed health status in people with hard-to-heal diabetic foot ulcers extending into tendon.METHODS: This is a health related quality of life sub-group analysis from a randomized controlled trial evaluating the effect of weekly applications of an autologous platelet and leucocyte patch (3C Patch). After a 4 week run-in-period those with a reduction in ulcer area of < 50% were randomized to either pre-specified good standard care alone or care supplemented by weekly application of the patch. The primary outcome showed a 1.58 (95% CI 1.06 - 2.35; p= 0.024) higher healing rate in the intervention group. Study participants reported their HRQoL using EQ-5D at baseline and after 12 and 20 weeks. In this analysis participants with ulcers extending into tendon were included.RESULTS: 18 people (10 intervention and 8 controls) were included. At the 20 week follow-up visit 40% of the participants in 3C Patch group improved at least one level in the dimension usual activities (p=0.046, Wilcoxon Rank-test) and 30% at least one level in mobility (n.s) compared to baseline. In the control group no improvements in any of the five HRQoL dimensions could be seen. CONCLUSIONS: The use of 3C Patch in people with hard to heal diabetic foot ulcers extending to tendon is associated with improved ability to cope with usual daily activities.

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