Wound Healing Society

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Correlation Of Dynamics Myocardial Infarction With Circulation Of Different Types Of Cryoglobulins
Ekaterina Konstantinova1, A.A. Bogdanova1, I.I. Eremin1, N.A. Shostak1, Natalia Konstantinova2.
1moscow medical university, moscow, Russian Federation, 2ST. John medical, atlanta, GA, USA.

Cryoglobulins (CG) are aggregates of immunoglobulin that precipitate from serum at reduced temperatures. The major clinical manifestations of CG is inflammation of small vessels, which seen at myocardial infarction (MI). There are three types of CG. Type I CG are monoclonal IgM. Type II CGs, complexes between polyclonal IgG and monoclonal IgM anti-IgG. The IgM anti-IgG binds to IgG, Fab fragments and Fc fragments, thus forming immune complexes.Type III AGs have polyclonal IgG and polyclonal IgM in the cryoglobulin immune complexes. We studied the level of all 3 types of CGs during acute Q-MI, at days 1,3,5,7,12,14. 33 patients (19 male and 14 female from ICUnit), and 23 control group, age from 35 to 57. Spectrophotometer have been used to measure the level of CGS. We found - at day 1, acute Q-MI - high level of type III CGs (high level of IgG, and IgM), if level of IgM went up to the day 3, and then slowly decreased, IgG, dropped to the day 7 , and then went up again. Fibronectin, went up to day 3, dropped by day 7, and went up again (same with IgM pattern). We might conclude, during acute phase of MI, type III cryoglobulins with fibronectin is dominate up to day 3. CG types chances with clinical dynamics, showing importance of CG in pathogenesis of MI.


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