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Effectiveness Of Amniotic Membrane And Umbilical Cord Particulate For Pressure Ulcers: A Retrospective Study
Anne T. Mancino, Alison Acott, Kathryn P. Brinegar.
CAVHS, Little Rock, AR, USA.

BACKGROUND: Pressure ulcers (PUs) are a prevalent clinical problem and only ~43% of PUs heal, which is the lowest wound healing rate among uncomplicated wounds. Amniotic membrane and umbilical cord (AMUC) contains anti-inflammatory, anti-scarring, and pro-regenerative properties. The objective of this study was to evaluate the effectiveness of AMUC particulate for recalcitrant PUs.
METHODS: Medical records were retrospectively reviewed to identify patients that received injection of amniotic membrane and umbilical cord (AMUC) particulate for recalcitrant PUs between 2017 and 2018. Data collected included patient age, significant medical comorbidities, wound location, PU stage, previous therapy, and wound dimensions. Time to wound healing and incidence of wound healing was assessed at 12, 24, 36, and 52 weeks.
RESULTS: A total of 26 PU wounds (85% stage IV, average volume 47.1 81.9 cm3) received AMUC. After treatment, 14 (54%) PUs achieved complete wound closure in a median time of 12.4 weeks (range 5-52). Complete wound closure was observed in 7 (27%) at 12 weeks, 10 (38%) at 24 weeks, 13 (50%) at 36 weeks, and 14 (54%) at 52 weeks. One patient with vascular issues at the time of treatment required amputation, however, no adverse events or complications related to treatment were observed.
CONCLUSIONS: These preliminary results suggest that injection of AMUC particulate may be a safe and promising treatment in promoting wound closure of difficult to treat PUs.


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