WOUND HEALING SOCIETY
2021 VIRTUAL PROGRAM
*All times are in Central Standard Time
(For full SAWC/WHS Program visit the SAWC website)
Program & Abstracts | Virtual Webinar
DAY 1: WEDNESDAY, MAY 12, 2021
9:45 AM - 10:45 AM CT
WHS SESSION 1: Mechanobiology of Wound Healing
Skin is constantly exposed to mechanical forces. Wounding significantly alters this environment leading to a disruption in mechanical homeostasis and alterations in mechanotransduction. These mechanical cues not only alter cellular function but also alter extracellular matrix stiffness and organization and are powerful mediators of both normal and abnormal healing. This session will explore how the mechanical environment controls wound healing from inflammation to remodeling and will discuss recent advances in therapies aimed at controlling the mechanical environment of healing wounds.
| Moderators: | Mitchell Sanders, PhD; Anie Philip, PhD |
| Speakers: | Boris Hinz, PhD; Ashley C. Brown, PhD |
Skin is constantly exposed to mechanical forces. Wounding significantly alters this environment leading to a disruption in mechanical homeostasis and alterations in mechanotransduction. These mechanical cues not only alter cellular function but also alter extracellular matrix stiffness and organization and are powerful mediators of both normal and abnormal healing. This session will explore how the mechanical environment controls wound healing from inflammation to remodeling and will discuss recent advances in therapies aimed at controlling the mechanical environment of healing wounds.
11:00 AM - 12:00 PM CT
WHS SESSION CONCURRENT ORAL ABSTRACTS I
Oral abstract presentations will feature the highest scoring abstracts submitted to the WHS.
Oral abstract presentations will feature the highest scoring abstracts submitted to the WHS.
Concurrent Oral Abstract Session 1A: Clinical
Moderator: Harvey N. Himel, MD
Moderator: Harvey N. Himel, MD
A1. A Phase 3 Open-label, Controlled, Randomized Trial Evaluating The Efficacy And Safety Of Bioengineered Regenerative Skin Construct In Patients With Deep Partial-thickness Thermal Burns
Angela Gibson1, James Holmes2, Jeffrey Shupp3, David Smith4, Victor Joe5, Joshua Carson6, Jeffrey Litt7, Steven Kahn8, Tracee Short9, Leopoldo Cancio10, Julie Rizzo10, Jeffrey Carter11, Kevin Foster12, B. Lynn Allen-Hoffmann1
1University of Wisconsin School of Medicine and Public Health, Madison, WI, USA, 2Wake Forest University School of Medicine, Winston-Salem, NC, USA, 3Medstar Washington Hospital, Washington DC, DC, USA, 4University of South Florida, Tampa, FL, USA, 5University of California at Irvine, Irvine, CA, USA, 6University of Florida, Gainesville, FL, USA, 7University of Missouri Health Care, Columbia, MO, USA, 8Medical University of South Carolina, Charleston, SC, USA, 9Baton Rouge General Medical Center, Baton Rouge, LA, USA, 10United States Army Institute of Surgical Research, Houston, TX, USA, 11Louisiana State University School of Medicine, New Orleans, LA, USA, 12The Arizona Burn Center at MIHS, Phoenix, AZ, USA
Angela Gibson1, James Holmes2, Jeffrey Shupp3, David Smith4, Victor Joe5, Joshua Carson6, Jeffrey Litt7, Steven Kahn8, Tracee Short9, Leopoldo Cancio10, Julie Rizzo10, Jeffrey Carter11, Kevin Foster12, B. Lynn Allen-Hoffmann1
1University of Wisconsin School of Medicine and Public Health, Madison, WI, USA, 2Wake Forest University School of Medicine, Winston-Salem, NC, USA, 3Medstar Washington Hospital, Washington DC, DC, USA, 4University of South Florida, Tampa, FL, USA, 5University of California at Irvine, Irvine, CA, USA, 6University of Florida, Gainesville, FL, USA, 7University of Missouri Health Care, Columbia, MO, USA, 8Medical University of South Carolina, Charleston, SC, USA, 9Baton Rouge General Medical Center, Baton Rouge, LA, USA, 10United States Army Institute of Surgical Research, Houston, TX, USA, 11Louisiana State University School of Medicine, New Orleans, LA, USA, 12The Arizona Burn Center at MIHS, Phoenix, AZ, USA
A2. A Non-Contact Device For Fast Screening Of Wound Infections
Jon Senkowsky1, Shuxin Li2, Ashwin Nair2, Suvra Pal3, Wenjing Hu2, Liping Tang2
1Texas Health Physician's group, Arlington, TX, USA, 2Progenitec Inc., Arlington, TX, USA, 3University of Texas at Arlington, Arlington, TX, USA
Jon Senkowsky1, Shuxin Li2, Ashwin Nair2, Suvra Pal3, Wenjing Hu2, Liping Tang2
1Texas Health Physician's group, Arlington, TX, USA, 2Progenitec Inc., Arlington, TX, USA, 3University of Texas at Arlington, Arlington, TX, USA
A3. Toward A Deeper Understanding Of Recurrent Pressure Injury Risk
Kath M. Bogie1, Katelyn Schwartz2, Kristi Henzel2, Mary Ann Richmond2, Ricky Chan1
1Case Western Reserve University, Cleveland, OH, USA, 2Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA
Kath M. Bogie1, Katelyn Schwartz2, Kristi Henzel2, Mary Ann Richmond2, Ricky Chan1
1Case Western Reserve University, Cleveland, OH, USA, 2Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA
A4. Identification Of Non-healing Wounds Using One-time Wound Alkalinity Measurement
Jon Senkowsky1, Shuxin Li2, Ashwin Nair2, Suvra Pal3, Wenjing Hu2, Liping Tang2
1Texas Health Physician's group, Arlington, TX, USA, 2Progenitec Inc., Arlington, TX, USA, 3University of Texas at Arlington, Arlington, TX, USA
Jon Senkowsky1, Shuxin Li2, Ashwin Nair2, Suvra Pal3, Wenjing Hu2, Liping Tang2
1Texas Health Physician's group, Arlington, TX, USA, 2Progenitec Inc., Arlington, TX, USA, 3University of Texas at Arlington, Arlington, TX, USA
A5. Assessing The Uncertainty Of Treatment Outcomes In Venous Leg Ulcer Randomized Controlled Trials: Secondary Analysis Of A Previous Systematic Review
Marissa J. Carter, Kristen A. Eckert
Strategic Solutions, Inc, Bozeman, MT, USA
Marissa J. Carter, Kristen A. Eckert
Strategic Solutions, Inc, Bozeman, MT, USA
Concurrent Oral Abstract Session 1B: Novel Therapies
Moderator: Timothy King, MD
Moderator: Timothy King, MD
B1. Inhibition Of Cysteine Protease Cathepsin K Accelerates Wound Healing In A Diabetic Porcine Model
Anne Chenchar1, Mary Freeman1, Brenda M. Alexander1, Amanda E. Louiselle2, Stephen M. Niemiec2, Mark W. Azeltine Bannerman2, Carlos Zgheib2, Kenneth W. Liechty2, S Nair1
1University of Wyoming, Laramie, WY, USA, 2University of Colorado Denver School of Medicine and Children's Hospital Colorado, Aurora, CO, USA
Anne Chenchar1, Mary Freeman1, Brenda M. Alexander1, Amanda E. Louiselle2, Stephen M. Niemiec2, Mark W. Azeltine Bannerman2, Carlos Zgheib2, Kenneth W. Liechty2, S Nair1
1University of Wyoming, Laramie, WY, USA, 2University of Colorado Denver School of Medicine and Children's Hospital Colorado, Aurora, CO, USA
B2. Staged Dermal-hypodermal Xenografting To Model Trilaminar Human Skin In The Murine Host
Phoebe L. Lee1, Shawn J. Loder1, Patricia A. Leftwich1, Wayne V. Nerone1, Kacey G. Marra1, Lauren E. Kokai1, J. Peter Rubin2
1University of Pittsburgh, Pittsburgh, PA, USA, 2University of Pittsburgh, Pittsburgh, PA, USA
Phoebe L. Lee1, Shawn J. Loder1, Patricia A. Leftwich1, Wayne V. Nerone1, Kacey G. Marra1, Lauren E. Kokai1, J. Peter Rubin2
1University of Pittsburgh, Pittsburgh, PA, USA, 2University of Pittsburgh, Pittsburgh, PA, USA
B3. Bandage-like Nanogenerator-driven Electrical Stimulation Enhances Wound Healing In Human Skin
Aiping Liu, Yin Long, Jun Li, Lily Meronek, Xudong Wang, Angela Gibson
University of Wisconsin-Madison, Madison, WI, USA
Aiping Liu, Yin Long, Jun Li, Lily Meronek, Xudong Wang, Angela Gibson
University of Wisconsin-Madison, Madison, WI, USA
B4. Suitability Of Wound Care Dressings And Solutions For Use With Stratagraft Skin Tissue
Ashley Schwarzenstein1, Kenneth Gratz1, Janice Smiell2, Randi Rutan2, Helen Hahn2, Allen Comer1
1Mallinckrodt Pharmaceuticals, Madison, WI, USA, 2Mallinckrodt Pharmaceuticals, Bedminster, NJ, USA
Ashley Schwarzenstein1, Kenneth Gratz1, Janice Smiell2, Randi Rutan2, Helen Hahn2, Allen Comer1
1Mallinckrodt Pharmaceuticals, Madison, WI, USA, 2Mallinckrodt Pharmaceuticals, Bedminster, NJ, USA
B5. Fat Grafting For The Dysesthetic Digit: A Discussion Of Technique And Pilot Data
Shawn J. Loder1, Elizabeth A. Moroni1, Justine Kim1, J Peter Rubin2, Alexander Spiess1
1Pittsburgh, Pittsburgh, PA, USA, 2University of Pittsburgh, Pittsburgh, PA, USA
Shawn J. Loder1, Elizabeth A. Moroni1, Justine Kim1, J Peter Rubin2, Alexander Spiess1
1Pittsburgh, Pittsburgh, PA, USA, 2University of Pittsburgh, Pittsburgh, PA, USA
Concurrent Oral Abstract Session 1C: Bioengineering/Biomaterials
Moderator: Mitchell Sanders, PhD
Moderator: Mitchell Sanders, PhD
C1. Fibronectin Functionalized Collagen Scaffold Preferentially Promotes Vascular Smooth Muscle Cells Proliferation And Promotes Stronger Vascular Formation Via Alpha-v Beta-3 Integrin Interactions
Kaiti Duan, Biraja Dash, Henry Hsia
Yale School of Medicine, New Haven, CT, USA
Kaiti Duan, Biraja Dash, Henry Hsia
Yale School of Medicine, New Haven, CT, USA
C2. Effect Of Dehydrated Amnion Chorion Membranes On Mesenchymal Stem Cells In Vitro
Katrina Harmon, John McQuilling, Katie Mowry
Organogenesis Inc, Birmingham, AL, USA
Katrina Harmon, John McQuilling, Katie Mowry
Organogenesis Inc, Birmingham, AL, USA
C3. Mechanical Properties And In Vitro Characterization Of A Tri-layer Placental Allograft Membrane
Paul Bonvallet, Sita Damaraju, Heli Modi, Victoria Stefanelli, Sunil Saini, Ankur Gandhi
Integra Lifesciences, Princeton, NJ, USA
Paul Bonvallet, Sita Damaraju, Heli Modi, Victoria Stefanelli, Sunil Saini, Ankur Gandhi
Integra Lifesciences, Princeton, NJ, USA
C4. Dehydrated Amniotic And Placental Membrane Allografts Confer Beneficial Immunomodulation For Tissue Regeneration
Victoria Stefanelli, Paul Bonvallet, Sita Damaraju, Heli Modi, Sunil Saini, Ankur Gandhi
Integra LifeSciences, Princeton, NJ, USA
Victoria Stefanelli, Paul Bonvallet, Sita Damaraju, Heli Modi, Sunil Saini, Ankur Gandhi
Integra LifeSciences, Princeton, NJ, USA
C5. Mechanical Activation Of Inflammation At The Implant-tissue Interface Underlies Pathological Foreign Body Response
Jagannath Padmanabhan1, Kellen Chen1, Clark A. Bonham1, Britta A. Kuehlmann1, Teruyuki Dohi1, Dominic Henn1, Zachary A. Stern-Buchbinder1, Peter A. Than1, Hadi S. Hosseini1, Noah J. Magbual1, Mimi Borrelli1, Dharshan Sivaraj1, Artem A. Trotsyuk1, Sun Hyung Kwon1, Zeshaan Maan1, Michael Januszyk1, Lukas Prantl2, Geoffrey C. Gurtner1
1Department of Surgery, Stanford University, Stanford, CA, USA, 2Center of Plastic, Aesthetic, Hand and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany
Jagannath Padmanabhan1, Kellen Chen1, Clark A. Bonham1, Britta A. Kuehlmann1, Teruyuki Dohi1, Dominic Henn1, Zachary A. Stern-Buchbinder1, Peter A. Than1, Hadi S. Hosseini1, Noah J. Magbual1, Mimi Borrelli1, Dharshan Sivaraj1, Artem A. Trotsyuk1, Sun Hyung Kwon1, Zeshaan Maan1, Michael Januszyk1, Lukas Prantl2, Geoffrey C. Gurtner1
1Department of Surgery, Stanford University, Stanford, CA, USA, 2Center of Plastic, Aesthetic, Hand and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany
12:10 PM - 1:10 PM CT
WHS SESSION 3: Meeting the Needs of Our Diverse Patient Population: Wound Healing Challenges That Differ Across Fitzpatrick Skin Types
Skin color can be associated with wound healing phenotypes and differences in resultant closed wound and scar. In this session we will examine the continuum of scarring and how lesions vary based on skin color. We will focus on dyspigmentation or dyschromia and extreme examples of scarring such as keloids.
| Moderators: | Jeffrey W. Shupp, MD; Robel Beyene, MD |
| Speakers: | Dorothy M. Supp, PhD; Bonnie Carney, PhD |
Skin color can be associated with wound healing phenotypes and differences in resultant closed wound and scar. In this session we will examine the continuum of scarring and how lesions vary based on skin color. We will focus on dyspigmentation or dyschromia and extreme examples of scarring such as keloids.
1:20 PM - 2:20 PM CT
WHS SESSION 4: CONCURRENT ORAL ABSTRACTS II
Oral abstract presentations will feature the highest scoring abstracts submitted to the WHS.
Oral abstract presentations will feature the highest scoring abstracts submitted to the WHS.
Concurrent Oral Abstract Session 2D: Acute Wounds/Inflammation
Moderator: Katherine Radek, PhD
Moderator: Katherine Radek, PhD
D1. Skin Wounding Induces Cognitive And Behavioral Alterations And Modulates Cytokine Expression In The Murine Hippocampus
Daniel Fregoso1, Yasmin Hadian1, Anthony Gallegos1, John Maaga1, Isaiah Kletenik2, Melanie Gareau1, Rivkah Isseroff1
1UC Davis, Sacramento, CA, USA, 2Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA
Daniel Fregoso1, Yasmin Hadian1, Anthony Gallegos1, John Maaga1, Isaiah Kletenik2, Melanie Gareau1, Rivkah Isseroff1
1UC Davis, Sacramento, CA, USA, 2Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA
D2. Transcriptome Analysis Identifies Differentially Regulated Genes Contributing To Hematological Response After Radiation Exposure In A Mouse Model
Abdulnaser Alkhalil1, John Clifford2, Stacy Miller3, Ross Campbell4, Aarti Gautam5, Marti Jett5, Rasha Hammamieh5, Lauren Moffatt1, Jeffrey Shupp1
1MedStar Health Research Institute, Washington, DC, USA, 2USAISR, San Antonio, TX, USA, 3The Oak Ridge Institute for Science and Education, Fort Detrick, MD, USA, 4The Geneva Foundation, Washington, DC, USA, 5Walter Reed Army Institute of Research, Silver Spring, MD, USA
Abdulnaser Alkhalil1, John Clifford2, Stacy Miller3, Ross Campbell4, Aarti Gautam5, Marti Jett5, Rasha Hammamieh5, Lauren Moffatt1, Jeffrey Shupp1
1MedStar Health Research Institute, Washington, DC, USA, 2USAISR, San Antonio, TX, USA, 3The Oak Ridge Institute for Science and Education, Fort Detrick, MD, USA, 4The Geneva Foundation, Washington, DC, USA, 5Walter Reed Army Institute of Research, Silver Spring, MD, USA
D3. Pseudomonas Aeruginosa Theft Biofilm Requires Host Lipidsof Cutaneous Wound
Nandini Ghosh1, Mithun Sinha1, Dayanjan S. Wijesinghe2, Shomita S. Mathew-Steiner1, Amitava Das1, Kanhaiya Singh1, Mohamed El Masry1, Savita Khanna1, Hiroyuki Inoue3, Katsuhisa Yamazaki3, Manabu Kawada3, Gayle M. Gordillo1, Sashwati Roy1, Chandan K. Sen1
1Indiana University, Indianapolis, IN, USA, 2Virginia Commonwealth University, Richmond, VA, USA, 3Institute of Microbial Chemistry, Microbial Chemistry Research Foundation, Tokyo, Japan
Nandini Ghosh1, Mithun Sinha1, Dayanjan S. Wijesinghe2, Shomita S. Mathew-Steiner1, Amitava Das1, Kanhaiya Singh1, Mohamed El Masry1, Savita Khanna1, Hiroyuki Inoue3, Katsuhisa Yamazaki3, Manabu Kawada3, Gayle M. Gordillo1, Sashwati Roy1, Chandan K. Sen1
1Indiana University, Indianapolis, IN, USA, 2Virginia Commonwealth University, Richmond, VA, USA, 3Institute of Microbial Chemistry, Microbial Chemistry Research Foundation, Tokyo, Japan
D4. Immunosuppressive Effects Of Blast Overpressure Exposure In A Murine Model Of Combat Trauma
Brittany I. Garry, Alexander Bobrov, Radmila Pavlovic, Yonas Alamneh, Lanier Heyburn, Jessica Bolton, Joseph Long, Brett Swierczewski, Derese Getnet, Elke Bergmann-Leitner, V.Sujith Sajja, Vlado Antonic
Walter Reed Army Institute of Research, Silver Spring, MD, USA
Brittany I. Garry, Alexander Bobrov, Radmila Pavlovic, Yonas Alamneh, Lanier Heyburn, Jessica Bolton, Joseph Long, Brett Swierczewski, Derese Getnet, Elke Bergmann-Leitner, V.Sujith Sajja, Vlado Antonic
Walter Reed Army Institute of Research, Silver Spring, MD, USA
D5. Cell Therapy Stimulates Antimicrobial Properties Of Venous Leg Ulcers Via Perforin-2
Vivien Chen, Rivka Stone, Jamie L. Burgess, Natasa Strbo, Irena Pastar, Marjana Tomic-Canic
University of Miami Miller School of Medicine, Miami, FL, USA
Vivien Chen, Rivka Stone, Jamie L. Burgess, Natasa Strbo, Irena Pastar, Marjana Tomic-Canic
University of Miami Miller School of Medicine, Miami, FL, USA
Concurrent Oral Abstract Session 2E: Fibrosis/Scarring
Moderator: Anie Philip, PhD
Moderator: Anie Philip, PhD
E1. Single Cell RNA Sequencing Reveals Fibroblast Heterogeneity Across Embryonic Origins Of Skin
Michelle Griffin, Megan King, Kellen Chen, Heather desJardins-Park, Shamik Mascharak, Evan Fahy, Nicholas Guardino, Christopher Lavin, Darren Abbas, Michael Januszyk, Derrick Wan, Michael Longaker
Stanford Univeristy, Palo Alto, CA, USA
Michelle Griffin, Megan King, Kellen Chen, Heather desJardins-Park, Shamik Mascharak, Evan Fahy, Nicholas Guardino, Christopher Lavin, Darren Abbas, Michael Januszyk, Derrick Wan, Michael Longaker
Stanford Univeristy, Palo Alto, CA, USA
E2. Analysis Of HOX Gene Expression And The Effects Of HOXA9 Overexpression In Fibroblasts Derived From Keloid Lesions And Normal Skin
Dorothy M. Supp1, Jennifer M. Hahn2, Kevin L. McFarland2, Kelly A. Combs2, Meridith Anness1
1University of Cincinnati, Cincinnati, OH, USA, 2Shriners Hospitals for Children - Cincinnati, Cincinnati, OH, USA
Dorothy M. Supp1, Jennifer M. Hahn2, Kevin L. McFarland2, Kelly A. Combs2, Meridith Anness1
1University of Cincinnati, Cincinnati, OH, USA, 2Shriners Hospitals for Children - Cincinnati, Cincinnati, OH, USA
E3. Disrupting Mechanotransduction Reduces Scar Formation And Restores Cellular Subpopulations In A Large Animal Model Of Skin Grafting
Kellen Chen, Dominic Henn, Clark A. Bonham, Chikage Noishiki, Janos A. Barrera, Theresa C. Carlomagno, Tara Shannon, Chyna J. Mays, Artem A. Trotsyuk, Jagannath Padmanabhan, Michael T. Longaker, Michael Januszyk, Geoffrey C. Gurtner
Stanford University, Palo Alto, CA, USA
Kellen Chen, Dominic Henn, Clark A. Bonham, Chikage Noishiki, Janos A. Barrera, Theresa C. Carlomagno, Tara Shannon, Chyna J. Mays, Artem A. Trotsyuk, Jagannath Padmanabhan, Michael T. Longaker, Michael Januszyk, Geoffrey C. Gurtner
Stanford University, Palo Alto, CA, USA
E4. Novel Genetic Analysis Of MRL Mice Reveals That Complement Inhibition By Factor H Reduces Scarring
Heather E. desJardins-Park1, Katya L. Mack2, Nicholas Guardino1, Michelle Griffin1, Michael F. Davitt1, Shamik Mascharak1, Derrick C. Wan1, Hunter B. Fraser2, Michael T. Longaker1
1Stanford University School of Medicine, Stanford, CA, USA, 2Stanford University, Stanford, CA, USA
Heather E. desJardins-Park1, Katya L. Mack2, Nicholas Guardino1, Michelle Griffin1, Michael F. Davitt1, Shamik Mascharak1, Derrick C. Wan1, Hunter B. Fraser2, Michael T. Longaker1
1Stanford University School of Medicine, Stanford, CA, USA, 2Stanford University, Stanford, CA, USA
E5. Evaluating The Effects Of Fibroblast-Specific NF-Kβ Signaling On Scar Formation
David M. Chesko, Traci A. Wilgus.
Ohio State University, Columbus, OH, USA
David M. Chesko, Traci A. Wilgus.
Ohio State University, Columbus, OH, USA
Concurrent Oral Abstract Session 2F: Regeneration
Moderator: Daria A. Narmoneva, PhD
Moderator: Daria A. Narmoneva, PhD
F1. Reactive Oxygen Species Signaling: A Therapeutic Target For Wound Healing And Regeneration
Alanna V. Van Huizen, Luke J. Kinsey, Jacqueline M. Greene, Wendy S. Beane
Western Michigan University, Kalamazoo, MI, USA
Alanna V. Van Huizen, Luke J. Kinsey, Jacqueline M. Greene, Wendy S. Beane
Western Michigan University, Kalamazoo, MI, USA
F2. Transgenic Inhibition Of Engrailed-1 Results In Endogenous Postnatal Skin Regeneration
Shamik Mascharak, Heather E. desJardins-Park, Michael F. Davitt, Kellen Chen, Michelle Griffin, Nicholas Guardino, H. Peter Lorenz, Derrick C. Wan, Geoffrey C. Gurtner, Michael T. Longaker
Stanford University School of Medicine, Stanford, CA, USA
Shamik Mascharak, Heather E. desJardins-Park, Michael F. Davitt, Kellen Chen, Michelle Griffin, Nicholas Guardino, H. Peter Lorenz, Derrick C. Wan, Geoffrey C. Gurtner, Michael T. Longaker
Stanford University School of Medicine, Stanford, CA, USA
F3. Whole-transcriptome Analysis Demonstrates Evolving Transcriptional Human Response To Injury In Acute Wounds And Scars
Jamie Oh, Stephen Sibbett, Lara Muffley, Shari Honari, Theo Bammler, James W. Macdonald, Saman Arbabi, Nicole S. Gibran
University of Washington, Seattle, WA, USA
Jamie Oh, Stephen Sibbett, Lara Muffley, Shari Honari, Theo Bammler, James W. Macdonald, Saman Arbabi, Nicole S. Gibran
University of Washington, Seattle, WA, USA
F4. Ability Of The Panniculus Carnosus To Distribute Load Suggests Possible Reason For Pressure Injury Recurrence Following Poor Regeneration Of The Muscle
Nurul Jannah M. Nasir1, Alberto Corrias2, Johannes Heemskerk1, Eng Tat Ang2, Julia H. Jenkins1, Sandeep Sebastin3, Lisa Tucker-Kellogg1
1Duke-NUS Medical School, Singapore, Singapore, 2National University of Singapore, Singapore, Singapore, 3National University Health System, Singapore, Singapore
Nurul Jannah M. Nasir1, Alberto Corrias2, Johannes Heemskerk1, Eng Tat Ang2, Julia H. Jenkins1, Sandeep Sebastin3, Lisa Tucker-Kellogg1
1Duke-NUS Medical School, Singapore, Singapore, 2National University of Singapore, Singapore, Singapore, 3National University Health System, Singapore, Singapore
F5. Maximal Harvest Density Of Full-Thickness Skin Columns In Skin Replacement Therapy
Laura Cooper, Javier Chapa, Sean Christy, Rodney Chan, Anders Carlsson
US Army Institute of Surgical Research, San Antonio, TX, USA
Laura Cooper, Javier Chapa, Sean Christy, Rodney Chan, Anders Carlsson
US Army Institute of Surgical Research, San Antonio, TX, USA
2:30 PM - 3:30 PM CT
WHS SESSION 5: CONCURRENT ORAL ABSTRACTS III
Oral abstract presentations will feature the highest scoring abstracts submitted to the WHS.
Oral abstract presentations will feature the highest scoring abstracts submitted to the WHS.
Concurrent Oral Abstract Session 3G: Chronic Wounds
Moderator: Lindsay Kalan, PhD
Moderator: Lindsay Kalan, PhD
G1. Single-cell Transcriptomics Of Human Pressure Ulcers Reveals Mhcii Expressing Keratinocytes In Patients With A Worse Healing Outcome
Ning Xu Landén1, Dongqing Li1, Shangli Cheng1, Qiaolin Deng1, Pehr Sommar1, Yu Pei1, Jaanika Kärner1, Eva Herter1, Maria Toma1, Letian Zhang1, Kim Pham1, Xingqi Chen2, Liv Eidsmo1
1Karolinska Institute, Stockholm, Sweden, 2Uppsala University, Uppsala, Sweden
Ning Xu Landén1, Dongqing Li1, Shangli Cheng1, Qiaolin Deng1, Pehr Sommar1, Yu Pei1, Jaanika Kärner1, Eva Herter1, Maria Toma1, Letian Zhang1, Kim Pham1, Xingqi Chen2, Liv Eidsmo1
1Karolinska Institute, Stockholm, Sweden, 2Uppsala University, Uppsala, Sweden
G2. Cytoskeletal Deregulation In Non-Healing Chronic Wounds Inhibits Cell Migration And Wound Re-epithelialization
Beatriz Abdo Abujamra1, Jelena Marjanovic1, Rivka C. Stone1, Cheyanne R. Head1, Irena Pastar1, Juan P. Musi2, Fotios Andreopoulos3, Robert S. Kirsner1, Hadar Lev-Tov1, Marjana Tomic-Canic1, Ivan Jozic1
1University of Miami Miller School of Medicine, Miami, FL, USA, 2University of Miami School of Biomedical Engineering, Miami, FL, USA, 3University of Miami Miller School of Biomedical Engineering, Miami, FL, USA
Beatriz Abdo Abujamra1, Jelena Marjanovic1, Rivka C. Stone1, Cheyanne R. Head1, Irena Pastar1, Juan P. Musi2, Fotios Andreopoulos3, Robert S. Kirsner1, Hadar Lev-Tov1, Marjana Tomic-Canic1, Ivan Jozic1
1University of Miami Miller School of Medicine, Miami, FL, USA, 2University of Miami School of Biomedical Engineering, Miami, FL, USA, 3University of Miami Miller School of Biomedical Engineering, Miami, FL, USA
G3. The Effects Of Novel NRF2 Activators On Diabetic Wound Healing
May Barakat1, Brian David2, Kornelia Skowron2, Lin Chen1, Terry Moore2, Luisa DiPietro1
1University of Illinois at Chicago College of Dentistry, Chicago, IL, USA, 2University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA
May Barakat1, Brian David2, Kornelia Skowron2, Lin Chen1, Terry Moore2, Luisa DiPietro1
1University of Illinois at Chicago College of Dentistry, Chicago, IL, USA, 2University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA
G4. The Novel Role Of The Notch1 Signaling In Fibroblasts-Modulated Diabetic Wound Healing
Zhao-Jun Liu, Irena Pastar, Hongwei SHAO, YAN LI, Rochelle Prokupets, Sophia Liu, Kerstin Yu, Roberto I. Vazquez-Padron, Marjana Tomic-Canic, Omaida C. Velazquez
University of Miami, Miami, FL, USA
Zhao-Jun Liu, Irena Pastar, Hongwei SHAO, YAN LI, Rochelle Prokupets, Sophia Liu, Kerstin Yu, Roberto I. Vazquez-Padron, Marjana Tomic-Canic, Omaida C. Velazquez
University of Miami, Miami, FL, USA
G5. Characterizing Host-Microbiome Interactions In Response To Sharp Debridement In Diabetic Foot Ulcers
Shane Roesemann, Alex Cheong, Anna Tanaglia, Meghan Brennan, Lindsay Kalan
University of Wisconsin-Madison, Madison, WI, USA
Shane Roesemann, Alex Cheong, Anna Tanaglia, Meghan Brennan, Lindsay Kalan
University of Wisconsin-Madison, Madison, WI, USA
Concurrent Oral Abstract Session 3H: Chronic Wounds/ Epithelialization
Moderator: Jeffrey W. Shupp, MD
Moderator: Jeffrey W. Shupp, MD
H1. Mechanisms Of Chronic Wound Initiation
Proma Basu, Manuela Martins-Green
University of California Riverside, Riverside, CA, USA
Proma Basu, Manuela Martins-Green
University of California Riverside, Riverside, CA, USA
H2. Single-cell Rna-sequencing Identifies Novel Molecular Targets Of Endothelial Microrna-200b In Diabetic Ischemic Wound
Kanhaiya Singh, Priyanka Verma, Manishekhar Kumar, Edward Hernandez, Yashika Rustagi, Ahmed Abouhashem, Sanskruti Mahajan, Sujit Mohanty, Savita Khanna, Sashwati Roy, Chandan K. Sen
Indiana University School of Medicine, Indianapolis, IN, USA
Kanhaiya Singh, Priyanka Verma, Manishekhar Kumar, Edward Hernandez, Yashika Rustagi, Ahmed Abouhashem, Sanskruti Mahajan, Sujit Mohanty, Savita Khanna, Sashwati Roy, Chandan K. Sen
Indiana University School of Medicine, Indianapolis, IN, USA
H3. Oncostatin M Improves Cutaneous Wound Re-Epithelialization And Is Deficient Under Diabetic Conditions
AMITAVA Das, Nirupam Biswas, Nandini Ghosh, Mahadeo Gorain, Savita Khanna, Chandan K. Sen, Sashwati Roy
Indiana University, Indianapolis, IN, USA
AMITAVA Das, Nirupam Biswas, Nandini Ghosh, Mahadeo Gorain, Savita Khanna, Chandan K. Sen, Sashwati Roy
Indiana University, Indianapolis, IN, USA
H4. Soft Tissue Versus Bone Infection: Outcomes For Patients With Moderate To Severe Foot Infections
Amanda L. Killeen1, Kathryn Davis1, Matthew Malone2, Lawrence A. Lavery1
1University of Texas Southwestern, Dallas, TX, USA, 2South West Sydney Limb Preservation and Wound Research Academic Unit, Sydney, Australia
Amanda L. Killeen1, Kathryn Davis1, Matthew Malone2, Lawrence A. Lavery1
1University of Texas Southwestern, Dallas, TX, USA, 2South West Sydney Limb Preservation and Wound Research Academic Unit, Sydney, Australia
Concurrent Oral Abstract Session 3I: Technology
Moderator: Rivkah Isseroff, PhD
Moderator: Rivkah Isseroff, PhD
I1. The Impact Of Electroceutical Therapy On Acidity And Healing In Chronic Ischemic Wounds
Dhruv Sheshadri1, Bryan Hausman1, Katie Schwartz2, Jason Collins1, Josie Shiff1, Kath M. Bogie1
1Case Western Reserve University, Cleveland, OH, USA, 2Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA
Dhruv Sheshadri1, Bryan Hausman1, Katie Schwartz2, Jason Collins1, Josie Shiff1, Kath M. Bogie1
1Case Western Reserve University, Cleveland, OH, USA, 2Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA
I2. Developing Antibacterial Adhesives: Quaternary Ammonium Incorporation Into Cyanoacrylate Polymers
Cassandra Saitow, Rhi Stevens, Richard Gurney
Simmons University, Boston, MA, USA
Cassandra Saitow, Rhi Stevens, Richard Gurney
Simmons University, Boston, MA, USA
I3. Enzymatic Debridement Of Burn Wounds Using The Proteolytic Gel SN514
Angela R. Jockheck-Clark1, Randolph Stone, II1, Michelle Holik1, Lucy Schaffer1, Shanmugasundaram Natesan1, Aleksa Jovanovic2, Eric Roche2, Lei Shi2, Christy Robert1
1US Army Institute of Surgical Research, JBSA Fort Sam Houston, TX, USA, 2Smith & Nephew plc., Fort Worth, TX, USA
Angela R. Jockheck-Clark1, Randolph Stone, II1, Michelle Holik1, Lucy Schaffer1, Shanmugasundaram Natesan1, Aleksa Jovanovic2, Eric Roche2, Lei Shi2, Christy Robert1
1US Army Institute of Surgical Research, JBSA Fort Sam Houston, TX, USA, 2Smith & Nephew plc., Fort Worth, TX, USA
I4. Bioluminescence Imaging And Digital Planimetry In Stage 4 Pelvic Pressure Injuries: Preliminary Case Series
James B. Stiehl
St Mary's Hospital, Centralia, IL, USA
James B. Stiehl
St Mary's Hospital, Centralia, IL, USA
I5. Trade-offs Between Antiseptic Efficacy And Cytotoxicity In A Human Ex Vivo Wound Contamination Model
Alex Cheong, Clayton Rust, Aiping Liu, Lindsay Kalan, Angela Gibson
University of Wisconsin-Madison, Madison, WI, USA
Alex Cheong, Clayton Rust, Aiping Liu, Lindsay Kalan, Angela Gibson
University of Wisconsin-Madison, Madison, WI, USA
3:40 PM - 4:40 PM CT
WHS SESSION 6: Model Systems of Regeneration
The study of regeneration in wound healing can be accomplished in many different model systems, each with their own pros and cons. In this session, we will learn about the use of two unique model systems, the Zebrafish and the African Spiny Mouse and how their unique regenerative properties can be studied to improve wound healing in humans.
| Moderators: | Swathi Balaji, PhD; John Kubasiak, MD |
| Speakers: | Ashley Seifert, PhD; Anna Huttenlocher, MD |
The study of regeneration in wound healing can be accomplished in many different model systems, each with their own pros and cons. In this session, we will learn about the use of two unique model systems, the Zebrafish and the African Spiny Mouse and how their unique regenerative properties can be studied to improve wound healing in humans.
4:50 PM - 5:50 PM CT
WHS SESSION 7: CONCURRENT ORAL ABSTRACTS IV
Oral abstract presentations will feature the highest scoring abstracts submitted to the WHS.
Oral abstract presentations will feature the highest scoring abstracts submitted to the WHS.
Concurrent Oral Abstract Session 4J: ECM/Bioengineering/Biomaterials
Moderator: Swathi Balaji, PhD
Moderator: Swathi Balaji, PhD
J1. Immunomodulation Of Acellular Dermal Matrix Through Interleukin-4 Enhances Wound Healing And Biointegration
Hannah Kang1, Victoria Nash2, Greg Risser2, Meng Zhang1, Lisa Salopek1, Cassandra L. Fraser1, Christopher A. Campbell1, Kara L. Spiller2, Patrick S. Cottler1
1University of Virginia, Charlottesville, VA, USA, 2Drexel University, Philadelphia, PA, USA
Hannah Kang1, Victoria Nash2, Greg Risser2, Meng Zhang1, Lisa Salopek1, Cassandra L. Fraser1, Christopher A. Campbell1, Kara L. Spiller2, Patrick S. Cottler1
1University of Virginia, Charlottesville, VA, USA, 2Drexel University, Philadelphia, PA, USA
J2. Cysteine-rich Domain Of Type III Collagen N-propeptide Inhibits Fibroblast Activation By Attenuating Tgfβ Signaling
Becky K. Brisson, Daniel C. Stewart, Chelsea Burgwin, Susan W. Volk
University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA
Becky K. Brisson, Daniel C. Stewart, Chelsea Burgwin, Susan W. Volk
University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA
J3. Novel Antibiotic-Free Synthetic Wound Matrix Prevents Wound Infection And Promotes Healing
Ana Tellechea, Kushee-Nidhi Kumar, Ravi K. Mekala, Yewoo Lee, Seyedeh Zahra M. Madani, Hung-Yi Liu, Manav Mehta
Gel4Med Inc, Lowel, MA, USA
Ana Tellechea, Kushee-Nidhi Kumar, Ravi K. Mekala, Yewoo Lee, Seyedeh Zahra M. Madani, Hung-Yi Liu, Manav Mehta
Gel4Med Inc, Lowel, MA, USA
J4. Bioprinting Of Growth Factor Eluting Scaffold Improves Wound Healing
Kristo Nuutila1, Mohamadhamahdi Samandari2, Yori Endo1, Yuteng Zhang1, Jacob Quint2, Ali Tamayol2, Indranil Sinha1
1Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA, 2University of Connecticut Health Center, Farmington, CT, USA
Kristo Nuutila1, Mohamadhamahdi Samandari2, Yori Endo1, Yuteng Zhang1, Jacob Quint2, Ali Tamayol2, Indranil Sinha1
1Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA, 2University of Connecticut Health Center, Farmington, CT, USA
J5. Intradermal Delivery Of Vascular Endothelial Growth Factor With Fabricated Microneedle Arrays Accelerates Wound Healing
Mohamadmahdi Samandari1, Fariba Aghabaglou1, Kristo Nuutila2, Hossein Derakhshandeh1, Yuteng Zhang2, Yori Endo2, Seth Harris3, Craig Kreikemeier-Bower3, Elmira Arab-Tehrany4, Nicholas Peppas5, Ali Tamayol1, Indranil Sinha2
1University of Connecticut, Farmington, CT, USA, 2Brigham and Women's Hospital, Boston, MA, USA, 3University of Nebraska-Lincoln, Lincoln, NE, USA, 4Université de Lorraine, Nancy, France, 5University of Texas, Austin, TX, USA
Mohamadmahdi Samandari1, Fariba Aghabaglou1, Kristo Nuutila2, Hossein Derakhshandeh1, Yuteng Zhang2, Yori Endo2, Seth Harris3, Craig Kreikemeier-Bower3, Elmira Arab-Tehrany4, Nicholas Peppas5, Ali Tamayol1, Indranil Sinha2
1University of Connecticut, Farmington, CT, USA, 2Brigham and Women's Hospital, Boston, MA, USA, 3University of Nebraska-Lincoln, Lincoln, NE, USA, 4Université de Lorraine, Nancy, France, 5University of Texas, Austin, TX, USA
Concurrent Oral Abstract Session 4K: Aging/Inflammation
Moderator: Allen Holloway, MD
Moderator: Allen Holloway, MD
K1. Effect Of Senescent Cells Clearance On Wound Healing
Upasana Niyogi, Michel J. Ouellette, Mark A. Carlson
University of Nebraska Medical Center, Omaha, NE, USA
Upasana Niyogi, Michel J. Ouellette, Mark A. Carlson
University of Nebraska Medical Center, Omaha, NE, USA
K2. Injury To Fibroblast Monolayers Induces Expression Of Neutrophil Chemoattractants
Vlad Strumkovsky, Brian Kuhn, William J. Lindblad
Husson University, Bangor, ME, USA
Vlad Strumkovsky, Brian Kuhn, William J. Lindblad
Husson University, Bangor, ME, USA
K3. Aged And Apoptotic Neutrophil Derived Microparticles For Wound Healing
Gayathri Ganesh, Norifumi Urao
SUNY Upstate Medical University, Syracuse, NY, USA
Gayathri Ganesh, Norifumi Urao
SUNY Upstate Medical University, Syracuse, NY, USA
K4. Wound Reepithelialization And Inflammation Are Impaired In Perforin-2 Deficient Young And Aged Mice
Katelyn E. Rivas, Laura Padula, Eva Fisher, Cheyanne Head, Tongyu Wikramanayake, Irena Pastar, Marjana Tomic-Canic, Natasa Strbo
University of Miami, Miami, FL, USA
Katelyn E. Rivas, Laura Padula, Eva Fisher, Cheyanne Head, Tongyu Wikramanayake, Irena Pastar, Marjana Tomic-Canic, Natasa Strbo
University of Miami, Miami, FL, USA
K5. Induction Of Catalase And Estrogen Receptor Levels In Aged Adipose Derived Stem Cells Repletes Anti-oxidant Capacity To Restore A Young Pro-healing Phenotype
Rivka C. Stone1, Irena Pastar1, Paola Catanuto1, Simone Pereira-Simon1, Xiaomei Xia1, Cheyenne R. Head1, Sharon J. Elliot1, Marilyn K. Glassberg2, Marjana Tomic-Canic1
1University of Miami Miller School of Medicine, Miami, FL, USA, 2University of Arizona College of Medicine, Phoenix, AZ, USA
Rivka C. Stone1, Irena Pastar1, Paola Catanuto1, Simone Pereira-Simon1, Xiaomei Xia1, Cheyenne R. Head1, Sharon J. Elliot1, Marilyn K. Glassberg2, Marjana Tomic-Canic1
1University of Miami Miller School of Medicine, Miami, FL, USA, 2University of Arizona College of Medicine, Phoenix, AZ, USA
Concurrent Oral Abstract Session 4L: Adipose Tissue/ Chronic Wounds
Moderator: Kara L. Spiller, PhD
Moderator: Kara L. Spiller, PhD
L1. Plasmacytoid Dendritic Cells Regulate Th17 Activation In Diabetic Wound Cd4+ T-cells
Christopher O. Audu, Sonya Wolf, W. James Melvin, Frank Davis, Aaron denDekker, Sriganesh Sharma, Kevin Mangum, Emily Barrett, Amrita Joshi, Andrea Obi, Beth Moore, Katherine Gallagher
University of Michigan, Ann Arbor, MI, USA
Christopher O. Audu, Sonya Wolf, W. James Melvin, Frank Davis, Aaron denDekker, Sriganesh Sharma, Kevin Mangum, Emily Barrett, Amrita Joshi, Andrea Obi, Beth Moore, Katherine Gallagher
University of Michigan, Ann Arbor, MI, USA
L2. Subcutaneous Adipose PPAR Gamma Is Related With Promoted Healing In Obesity Wound
Ji LIN1, Xiao-ning GAO2
1Department of Basic Medicine, Graduate School, Chinese PLA General Hospital, Beijing, China, 2Department of Hematology, Chinese PLA General Hospital, Beijing, China
Ji LIN1, Xiao-ning GAO2
1Department of Basic Medicine, Graduate School, Chinese PLA General Hospital, Beijing, China, 2Department of Hematology, Chinese PLA General Hospital, Beijing, China
L3. Cxcr2 Links Senescence To Healing Pathology In Both Murine And Human Diabetic Wounds.
Holly Wilkinson, Paolo Matteucci, Matthew Hardman
Hull York Medical School, Hull, United Kingdom
Holly Wilkinson, Paolo Matteucci, Matthew Hardman
Hull York Medical School, Hull, United Kingdom
L4. Adipose-derived Regenerative Cells And Lipotransfer In Alleviating Breast Cancer-related Lymphedema: An Open-labeled Phase I Trial With 4 Years Follow Up
Mads Gustaf Jřrgensen
Odense University Hospital, Odense C, Denmark
Mads Gustaf Jřrgensen
Odense University Hospital, Odense C, Denmark
L5. Cryopreserved Adipose For Hypodermal Augmentation After Full-thickness Burns
Patricia A. Leftwich, Shawn J. Loder, Somaiah Chinnapaka, Wayne V. Nerone, Phoebe L. Lee, Kacey G. Marra, Asim Ejaz, Lauren E. Kokai, J. Peter Rubin
University of Pittsburgh, Pittsburgh, PA, USA
Patricia A. Leftwich, Shawn J. Loder, Somaiah Chinnapaka, Wayne V. Nerone, Phoebe L. Lee, Kacey G. Marra, Asim Ejaz, Lauren E. Kokai, J. Peter Rubin
University of Pittsburgh, Pittsburgh, PA, USA
DAY 2: THURSDAY, MAY 13, 2021
10:25 AM - 11:25 AM CT
WHS SESSION 8: Wound Healing Foundation Thomas K. Hunt Lecturer
The Thomas K. Hunt Endowed Lecture was established in 2013 to honor the legacy of Dr. Hunt who is a leader in wound healing research and a founding member of the Wound Healing Society. The purpose of this lecture is to inspire and educate wound healing researchers on related research innovations. Every year an honorary speaker is chosen by the Wound Healing Foundation and not limited to those who are directly involved in wound healing research but includes investigators who demonstrate the ability to bridge scientific gaps and cross boundaries through the use of basic physiology to understand healing processes in multiple organ systems. Noble prize recipient Dr Schekman will discuss how many cells secrete small extracellular vesicles (EVs) or exosomes. The EVs may carry proteins and RNA to target cells to change the pattern of gene expression or disease. His lab has found EVs isolated from fibroblasts or keratinocytes stimulate the migration of cells in a wound healing assay. By understanding the EV process, vesicles may be used to deliver therapeutic molecules for improved skin wound healing.
| Moderators: | Laura K.S. Parnell, BS, MS, CWS; Geoffrey C. Gurtner, MD, FACS |
| Speakers: | Randy W. Schekman, PhD |
The Thomas K. Hunt Endowed Lecture was established in 2013 to honor the legacy of Dr. Hunt who is a leader in wound healing research and a founding member of the Wound Healing Society. The purpose of this lecture is to inspire and educate wound healing researchers on related research innovations. Every year an honorary speaker is chosen by the Wound Healing Foundation and not limited to those who are directly involved in wound healing research but includes investigators who demonstrate the ability to bridge scientific gaps and cross boundaries through the use of basic physiology to understand healing processes in multiple organ systems. Noble prize recipient Dr Schekman will discuss how many cells secrete small extracellular vesicles (EVs) or exosomes. The EVs may carry proteins and RNA to target cells to change the pattern of gene expression or disease. His lab has found EVs isolated from fibroblasts or keratinocytes stimulate the migration of cells in a wound healing assay. By understanding the EV process, vesicles may be used to deliver therapeutic molecules for improved skin wound healing.
2:45 PM - 5:00 PM CT
WHS SESSION 9: YOUNG INVESTIGATORS SYMPOSIUM
| Moderators: | Irena Pastar, PhD; Daria A. Narmoneva, PhD |
In this session, young investigators involved in cutting-edge research will compete for the WHS Young Investigator Award. The winner will present his/her work at the ETRS meeting. Oral presentations will feature the top eight abstracts submitted to the WHS by young investigators as well as the winner of the ETRS Young Investigator Award.
YIA1. Wnt-active Engrailed-1 Lineage-negative Fibroblasts Mediate Postnatal Skin Regeneration
Shamik Mascharak, Heather E. desJardins-Park, Michael Januszyk, Kellen Chen, Michael F. Davitt, Janos Demeter, Dominic Henn, Michelle Griffin, Clark A. Bonham, Nancie Mooney, Ran Cheng, Peter K. Jackson, Derrick C. Wan, Geoffrey C. Gurtner, Michael T. Longaker
Stanford University School of Medicine, Stanford, CA, USA
Shamik Mascharak, Heather E. desJardins-Park, Michael Januszyk, Kellen Chen, Michael F. Davitt, Janos Demeter, Dominic Henn, Michelle Griffin, Clark A. Bonham, Nancie Mooney, Ran Cheng, Peter K. Jackson, Derrick C. Wan, Geoffrey C. Gurtner, Michael T. Longaker
Stanford University School of Medicine, Stanford, CA, USA
YIA2. MiR-193b-3p In Diabetic Foot Ulcers: A Master Regulator Of Impaired Wound Healing And A Tumor Protector
Jelena Marjanovic, Horacio A. Ramirez, Ivan Jozic, Rivka Stone, Tongyu C. Wikramanayake, Cheyanne R. Head, Beatriz Abdo Abujamra, Nkemcho Ojeh, Robert S. Kirsner, Hadar Lev-Tov, Irena Pastar, Marjana Tomic-Canic
Wound Healing and Regenerative Medicine Research Program, Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
Jelena Marjanovic, Horacio A. Ramirez, Ivan Jozic, Rivka Stone, Tongyu C. Wikramanayake, Cheyanne R. Head, Beatriz Abdo Abujamra, Nkemcho Ojeh, Robert S. Kirsner, Hadar Lev-Tov, Irena Pastar, Marjana Tomic-Canic
Wound Healing and Regenerative Medicine Research Program, Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA
YIA3. Adipocytes In Dermal Wounds Undergo Conversion To Pro-fibrotic Fibroblasts That Contribute To Scar Formation
Nicholas Guardino, Heather E. desJardins-Park, Michelle Griffin, Khristian E. Bauer-Rowe, Megan E. King, Megan E. King, Shamik Mascharak, Michael T. Longaker
Stanford Medical School, Stanford, CA, USA
Nicholas Guardino, Heather E. desJardins-Park, Michelle Griffin, Khristian E. Bauer-Rowe, Megan E. King, Megan E. King, Shamik Mascharak, Michael T. Longaker
Stanford Medical School, Stanford, CA, USA
YIA4. CRISPR/Cas9 Editing Of Autologous Dendritic Cells To Enhance Angiogenesis And Wound Healing
Dominic Henn1, Dehua Zhao2, Clark A. Bonham1, Kellen Chen1, Autumn H. Greco1, Jagannath Padmanabhan1, Dharshan Sivaraj1, Artem Trotsyuk1, Janos A. Barrera1, Michael Januszyk1, Lei Stanley Qi2, Geoffrey C. Gurtner1
1Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University, Stanford, CA, USA, 2Dept. of Bioengineering, Stanford University, Stanford, CA, USA
Dominic Henn1, Dehua Zhao2, Clark A. Bonham1, Kellen Chen1, Autumn H. Greco1, Jagannath Padmanabhan1, Dharshan Sivaraj1, Artem Trotsyuk1, Janos A. Barrera1, Michael Januszyk1, Lei Stanley Qi2, Geoffrey C. Gurtner1
1Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University, Stanford, CA, USA, 2Dept. of Bioengineering, Stanford University, Stanford, CA, USA
YIA5. Energy Metabolism Governs The Degree Of Fibrosis In Dermal Wound Healing
Umang M. Parikh1, Hima V. Vangapandu1, Harrison Strang1, Aditya Kaul1, Hui Li1, Cristian Coarfa1, Swathi Balaji2
1Baylor College of Medicine, Houston, TX, USA, 2Surgery, Baylor College of Medicine, Houston, TX, USA
Umang M. Parikh1, Hima V. Vangapandu1, Harrison Strang1, Aditya Kaul1, Hui Li1, Cristian Coarfa1, Swathi Balaji2
1Baylor College of Medicine, Houston, TX, USA, 2Surgery, Baylor College of Medicine, Houston, TX, USA
YIA6. Exosome Topical Therapy Delivered In Bioinspired Synthetic Protein Hydrogel Enhances Cutaneous Healing Of Diabetic Wounds
Juan F. Cortes Troncoso1, Joseph F. Kuhn1, Priya Katyal2, Bibi Subhan1, Iraines De La Cruz1, Michael Meleties2, Jin K. Montclare2, Piul S. Rabbani1
1New York University School of Medicine, New York, NY, USA, 2NYU Tandon School of Engineering, New York, NY, USA
Juan F. Cortes Troncoso1, Joseph F. Kuhn1, Priya Katyal2, Bibi Subhan1, Iraines De La Cruz1, Michael Meleties2, Jin K. Montclare2, Piul S. Rabbani1
1New York University School of Medicine, New York, NY, USA, 2NYU Tandon School of Engineering, New York, NY, USA
YIA7. Interleukin-10 Producing T-Lymphocytes Mitigate Dermal Fibrosis
Walker D. Short, Xinyi Wang, Hui Li, Ling Yu, Aditya Kaul, Swathi Balaji, Sundeep G. Keswani
Baylor College of Medicine, Houston, TX, USA
Walker D. Short, Xinyi Wang, Hui Li, Ling Yu, Aditya Kaul, Swathi Balaji, Sundeep G. Keswani
Baylor College of Medicine, Houston, TX, USA
YIA8. ELU42, A Small Molecule Wnt Signaling Inhibitor, Promotes Regenerative Repair Following Cutaneous And Cartilage Injury In Diabetic Mice
Dina Hassan1, Daniel Holsworth2, John Delgado2, Sarika Saraswati3
1Vanderbilt University Medical Center, Nashville, TN, USA, 2Eluciderm Inc, San Diego, CA, USA, 3Tennessee State University, Nashville, TN, USA
Dina Hassan1, Daniel Holsworth2, John Delgado2, Sarika Saraswati3
1Vanderbilt University Medical Center, Nashville, TN, USA, 2Eluciderm Inc, San Diego, CA, USA, 3Tennessee State University, Nashville, TN, USA
YIA9. ETRS WINNER
6:00 PM - 7:00 PM CT
WHS SESSION 10: Cancer and Chronic Wounds
The relationship between wound healing and cancer has long been recognized. The mechanisms that regulate wound healing have been shown to promote transformation and growth of malignant cells. In addition, chronic inflammation has been associated with malignant transformation in many tissues. This session will explore how similarities and differences between healing wounds and tumor stroma continue to evolve, shedding light on possible therapeutic targets that can result in innovative treatments for wound healing and/or cancer.
| Moderators: | Traci A. Wilgus, PhD ; Ardeshir Bayat, PhD |
| Speakers: | Brian Eliceiri, PhD; Alan Wells, MD, DMsC |
The relationship between wound healing and cancer has long been recognized. The mechanisms that regulate wound healing have been shown to promote transformation and growth of malignant cells. In addition, chronic inflammation has been associated with malignant transformation in many tissues. This session will explore how similarities and differences between healing wounds and tumor stroma continue to evolve, shedding light on possible therapeutic targets that can result in innovative treatments for wound healing and/or cancer.
DAY 3: FRIDAY, MAY 14, 2021
10:10 AM - 11:10 AM CT
WHS SESSION 11: ETRS/ WHS JOINT SESSION- Newest Technologies In Tissue Repair Research
New technologies drive biomedical research and enable unprecedented insight into mechanisms of tissue repair. In recent years, we have seen enormous progress in development and application of medical imaging modalities as well as systems biology approaches to decipher molecular dynamics down to the single-cell level. This session will demonstrate the transforming capabilities of these approaches for long-term imaging of wound angiogenesis and deciphering of multi-cellular dynamics in lung regeneration and fibrosis.
| Moderators: | Ulrich auf dem Keller, PhD; Adrian Barbul, MD |
| Speakers: | Herbert Schiller, MD (Online Virtual Zoom in only); Daniel Razansky, PhD |
New technologies drive biomedical research and enable unprecedented insight into mechanisms of tissue repair. In recent years, we have seen enormous progress in development and application of medical imaging modalities as well as systems biology approaches to decipher molecular dynamics down to the single-cell level. This session will demonstrate the transforming capabilities of these approaches for long-term imaging of wound angiogenesis and deciphering of multi-cellular dynamics in lung regeneration and fibrosis.
1:40 PM - 2:40 PM CT
WHS SESSION 12: Neuroinflammation
Wound healing is a significant challenge for systems biologists, as the injury is targeted to the local tissue, but the response to this injury elicits a systemic response. In addition to the trafficking of inflammatory (and anti-inflammatory cells) to the wound bed, the central and peripheral nervous systems (CNS and PNS) can participate in the repair and regenerative response. This session will review the mechanisms of nervous system involvement in injury, current concepts governing the efferent and afferent pathways affected by wounding, and the role played by neuro-inflammation.
| Moderators: | Katherine Radek, PhD; Andrew Baird, PhD |
| Speakers: | Rivkah Isseroff, MD; Daniel Kaplan, MD |
Wound healing is a significant challenge for systems biologists, as the injury is targeted to the local tissue, but the response to this injury elicits a systemic response. In addition to the trafficking of inflammatory (and anti-inflammatory cells) to the wound bed, the central and peripheral nervous systems (CNS and PNS) can participate in the repair and regenerative response. This session will review the mechanisms of nervous system involvement in injury, current concepts governing the efferent and afferent pathways affected by wounding, and the role played by neuro-inflammation.
3:40 PM - 4:40 PM CT
WHS SESSION 13: Wound Pathogens and the Microbiome
Microbes are known to impair healing and can cause infection and additional complication. The pathophysiological nature of these microbial communities and their roles in modulating the immunological and local wound milieu responses are being targeted for improved wound care practices. These presentations will highlight several advances in our current understanding of microbial communities and their interactions, wound pathogens, antimicrobial resistance and ongoing efforts to translate basic research findings to clinical wound care.
| Moderators: | Elizabeth Grice, PhD; Katherine Radek, PhD |
| Speakers: | Marvin Whiteley, PhD; Irena Pastar, PhD |
Microbes are known to impair healing and can cause infection and additional complication. The pathophysiological nature of these microbial communities and their roles in modulating the immunological and local wound milieu responses are being targeted for improved wound care practices. These presentations will highlight several advances in our current understanding of microbial communities and their interactions, wound pathogens, antimicrobial resistance and ongoing efforts to translate basic research findings to clinical wound care.
4:50 PM - 5:50 PM CT
WHS SESSION 14: Immunomodulatory Strategies for Wound Healing and Repair
All biomaterials elicit an immune response when implanted. While this response has historically been considered deleterious to wound healing, novel biomaterials have been developed to trigger desired tissue responses including angiogenesis and recruitment of pro-remodeling macrophages. This session will focus on recent advances in immunomodulatory biomaterials for enhanced wound repair.
| Moderators: | Mohamed M. Ibrahim, MD; Britani Blackstone, PhD |
| Speakers: | Edward Botchwey, PhD; Kara Spiller, PhD |
All biomaterials elicit an immune response when implanted. While this response has historically been considered deleterious to wound healing, novel biomaterials have been developed to trigger desired tissue responses including angiogenesis and recruitment of pro-remodeling macrophages. This session will focus on recent advances in immunomodulatory biomaterials for enhanced wound repair.
6:00 PM - 7:00 PM CT
WHS SESSION 15: WOUND HEALING FOUNDATION - WHF-MEDLINE CORIUS INNOVATION LECTURE
The purpose of this one-year Wound Healing Innovation Grant supported by Medline is to stimulate scientific research of young investigators or junior faculty who are pursuing a career in wound healing research and have innovative research that can potentially change or provide new therapies or products. Presentation of the second award will be made. In the WHF-Medline Corius Innovation Lecture, the inaugural recipient Ivan Jozic, PhD will present the results of his award-funded research on an innovative and potentially commercializable technology targeting caveolins in chronic wounds. A panel discussion on the research and technology prospective.
| Moderators: | Laura K. S. Parnell BS, MS, CWS; Gregory S. Schultz, PhD |
| Speakers: | Ivan Jozic, PhD |
The purpose of this one-year Wound Healing Innovation Grant supported by Medline is to stimulate scientific research of young investigators or junior faculty who are pursuing a career in wound healing research and have innovative research that can potentially change or provide new therapies or products. Presentation of the second award will be made. In the WHF-Medline Corius Innovation Lecture, the inaugural recipient Ivan Jozic, PhD will present the results of his award-funded research on an innovative and potentially commercializable technology targeting caveolins in chronic wounds. A panel discussion on the research and technology prospective.